Verteporfin

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Chemical Structure| 129497-78-5 同义名 : CL 318952; BPD-MA; DB00460, CL 318952, BPD-MA, BpdMA, Benzoporphyrin D, Benzoporphyrin derivative monoacid ring A, Verteporfin, Visudyne.
CAS号 : 129497-78-5
货号 : A138297
分子式 : C41H42N4O8
纯度 : 98%
分子量 : 718.79
MDL号 : MFCD28098202
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • VDA
描述 Verteporfin (CL 318952) is utilized as a photosensitizer in photodynamic therapy aimed at eradicating abnormal blood vessels in the eye, particularly in conditions like age-related macular degeneration. It also functions as a YAP inhibitor, effectively disrupting YAP-TEAD interactions and inducing apoptosis in cells[1]. Additionally, Verteporfin acts as an autophagy inhibitor, specifically blocking the early stages of autophagy by preventing autophagosome formation[3].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
ARPE-19 ~0.1 μg/ml cytotoxicity assay shows a dose-dependent toxicity 16987905
ARPE-19 0.01 μg/ml Function assay increases VEGF and reduces PEDF expression 16987905
ARPE-19 0.5 µg/ml cytotoxicity assay decreases viability by 55.5% 23441114
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00211484 Age-Related Macular Degenerati... 展开 >>ons. Subfoveal Neovascularization. 收起 << Phase 2 Completed - United States, New York ... 展开 >> Manhattan Eye, Ear & Throat Hospital New York, New York, United States, 10021 收起 <<
NCT02587767 Acute Central Serous Chorioret... 展开 >>inopathy 收起 << Not Applicable Active, not recruiting December 2018 China, Guangdong ... 展开 >> Zhongshan Ophthalmic Center, Sun Yat-sen University Guangzhou, Guangdong, China, 510060 收起 <<
NCT02072408 Polypoidal Choroidal Vasculopa... 展开 >>thy Without Active Polyp 收起 << Phase 4 Completed - Korea, Republic of ... 展开 >> Seoul National University Bundang Hospital Seongnam, Gyunggi-do, Korea, Republic of Konyang University Kim's Eye Hospital Seoul, Korea, Republic of Samsung Medical Center Seoul, Korea, Republic of 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.39mL

0.28mL

0.14mL

6.96mL

1.39mL

0.70mL

13.91mL

2.78mL

1.39mL
参考文献

[1]Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2.

[2]Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90.

[3]Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96.