Regorafenib monohydrate

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Chemical Structure| 1019206-88-2 同义名 : BAY 73-4506 monohydrate; Fluoro-sorafenib; regorafaenib monohydrate; Stivarga; Resihance; Regorafenib(monohydrate)
CAS号 : 1019206-88-2
货号 : A137952
分子式 : C21H17ClF4N4O4
纯度 : 98%
分子量 : 500.83
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.00mL

0.40mL

0.20mL

9.98mL

2.00mL

1.00mL

19.97mL

3.99mL

2.00mL
参考文献

[1]Carr BI, Cavallini A, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol. 2013 Feb;228(2):292-7.

[2]Wilhelm SM, Dumas J, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.