KI-7

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Chemical Structure| 1489263-00-4 同义名 : -
CAS号 : 1489263-00-4
货号 : A1379050
分子式 : C23H18N2O2
纯度 : 98%
分子量 : 354.4
MDL号 : MFCD34470323
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 KI-7 acts as a positive allosteric modulator of the A2B adenosine receptor. It enhances cAMP accumulation triggered by the non-selective A2B adenosine receptor agonist NECA, with an EC50 of 445.8 nM. Furthermore, KI-7 boosts cAMP accumulation in response to the selective A2B adenosine receptor agonist BAY 60-6583 and adenosine, with EC50 values of 2390 nM and 2550 nM, respectively[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL
参考文献

[1]Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203.

[2]Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843(12):2957-2966.