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同义名 : | - |
CAS号 : | 2290527-07-8 | |
货号 : | A1378671 | |
分子式 : | C25H23FN4O | |
纯度 : | 99% | |
分子量 : | 414.47 | |
MDL号 : | MFCD00868218 | |
存储条件: |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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溶解度 : | - | |
动物实验配方: |
生物活性 | |||
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描述 | Bractoppin is a potent and selective inhibitor of phosphopeptide recognition by the human BRCA1 tandem BRCT domain (IC50: 74 nM). It reduces BRCA1 recruitment to DNA breaks, thereby suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin predominantly inhibits BRCA1 tBRCT-dependent processes in the DNA damage response[1]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.41mL 0.48mL 0.24mL |
12.06mL 2.41mL 1.21mL |
24.13mL 4.83mL 2.41mL |
参考文献 |
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