Fisogatinib
产品说明书
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同义名 : | BLU-554 |
| CAS号 : | 1707289-21-1 | |
| 货号 : | A137706 | |
| 分子式 : | C24H24Cl2N4O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 503.38 | |
| MDL号 : | MFCD30496704 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | Fisogatinib, also known as BLU-554, is a strong, highly selective, and orally bioavailable inhibitor of FGFR4, exhibiting IC50 value of 5 nM. It demonstrates considerable efficacy against tumors in hepatocellular carcinoma (HCC) models that rely on FGFR4 signaling[1]. | ||
| 作用机制 | BLU-554 is a potent and highly selective FGFR4 inhibitor that covalently binds to FGFR4. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.99mL 0.40mL 0.20mL |
9.93mL 1.99mL 0.99mL |
19.87mL 3.97mL 1.99mL |
