BCH001

产品说明书

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Chemical Structure| 384859-58-9 同义名 : -
CAS号 : 384859-58-9
货号 : A1374315
分子式 : C20H15F3N2O5
纯度 : 99%+
分子量 : 420.34
MDL号 : MFCD02932975
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 BCH001, a quinoline derivative, acts as a specific inhibitor of PAPD5. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. It exhibits no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is utilized for regulating aging [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.90mL

2.38mL

1.19mL

23.79mL

4.76mL

2.38mL
参考文献

[1]Neha Nagpal, et al. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8.