KY19382

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Chemical Structure| 2226664-93-1 同义名 : A3051
CAS号 : 2226664-93-1
货号 : A1365458
分子式 : C17H11Cl2N3O2
纯度 : 98%+
分子量 : 360.19
MDL号 : MFCD32878265
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 KY19382 is a potent dual inhibitor of CXXC5-DVL and GSK3β, exhibiting IC50s of 19 and 10 nM, respectively. It activates Wnt/β-catenin signaling by inhibiting both the CXXC5-DVL interaction and GSK3β activity. KY19382 is suitable for investigating high fat diet (HFD)-induced metabolic diseases[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.88mL

2.78mL

1.39mL

27.76mL

5.55mL

2.78mL
参考文献

[1]Choi S, et, al. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth. Life Sci Alliance. 2019 Apr 10; 2(2): e201800254.

[2]Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569.