T025
产品说明书
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同义名 : | - |
| CAS号 : | 2407433-00-3 | |
| 货号 : | A1365253 | |
| 分子式 : | C21H18N8 | |
| 纯度 : | 99%+ | |
| 分子量 : | 382.42 | |
| MDL号 : | MFCD31813666 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | T025 is a potent, orally active inhibitor of Cdc2-like kinases (CLKs) with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5, and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B, and DYRK2, respectively. T025 induced caspase-3/7-mediated apoptosis in MDA-MB-468 cells at concentrations of 0, 10, 30, 100, 300 and 1000 nM for 6 h. T025 exhibited antiproliferative activity in both haematological and solid cancer cell lines tested (IC50 values: 30-300 nM). It has antitumour efficacy and is mainly used in MYC-driven disease studies[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.61mL 0.52mL 0.26mL |
13.07mL 2.61mL 1.31mL |
26.15mL 5.23mL 2.61mL |
