同义名 :	LY-674
	CAS号 :	425671-29-0
	货号 :	A1365021
	分子式 :	C23H27N3O4
	纯度 :	99%
	分子量 :	409.48
	MDL号 :	MFCD11977271
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	LY518674 acts as a potent, selective PPARα agonist, with an EC50 of 42 nM for human PPARα. This drug lowers triglycerides and raises HDL-C levels, making it suitable for treating atherosclerosis. The effects include not just lipid reduction in clinical settings but also improved outcomes in experimental models[1].[2].[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.44mL 0.49mL 0.24mL	12.21mL 2.44mL 1.22mL	24.42mL 4.88mL 2.44mL

参考文献

[1]Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. [2]Nissen SE, et al. Effects of a potent and selective PPAR-alpha agonist in patients with atherogenic dyslipidemia or hypercholesterolemia: two randomized controlled trials. JAMA. 2007 Mar 28;297(12):1362-73. [3]Khera AV, et al. Potent peroxisome proliferator-activated receptor-α agonist treatment increases cholesterol efflux capacity in humans with the metabolic syndrome. Eur Heart J. 2015 Nov 14;36(43):3020-2.