VTP50469
产品说明书
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同义名 : | - |
| CAS号 : | 2169916-18-9 | |
| 货号 : | A1364995 | |
| 分子式 : | C32H47FN6O4S | |
| 纯度 : | 98% | |
| 分子量 : | 630.82 | |
| MDL号 : | MFCD32197139 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | VTP50469 is a potent, highly selective and orally active inhibitor of Menin-MLL interaction with a Ki value of 104 pM. VTP50469 exhibits potent antileukaemic activity[1][2].At early time points, the MLL-r B-cell ALL (B-ALL) cell line, but not the MLL-r AML cell line, responds apoptotically to VTP50469 in a dose-dependent manner. The MLL-r AML cell line begins to dose-dependently differentiate after 4-6 days of exposure to VTP50469[1].VTP50469 displaces Menin from the protein complex and inhibits chromatin occupancy by MLL at specific genes. Loss of binding to MLL results in changes in gene expression, differentiation and apoptosis[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.59mL 0.32mL 0.16mL |
7.93mL 1.59mL 0.79mL |
15.85mL 3.17mL 1.59mL |
