Rheb inhibitor NR1
产品说明书
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同义名 : | - |
| CAS号 : | 2216763-38-9 | |
| 货号 : | A1364808 | |
| 分子式 : | C25H19BrCl2N2O3S | |
| 纯度 : | 99% | |
| 分子量 : | 578.3 | |
| MDL号 : | MFCD31714165 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Rheb inhibitor NR1 exhibits an IC50 of 2.1 µM in the Rheb-IVK assay. It directly binds Rheb in the switch II domain, selectively inhibiting the activation of mechanistic target of rapamycin complex 1 (mTORC1). NR1 inhibits T389pS6K1 phosphorylation by mTORC1 and enhances S473pAKT phosphorylation dose-dependently. It does not affect mTORC2 activity [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.73mL 0.35mL 0.17mL |
8.65mL 1.73mL 0.86mL |
17.29mL 3.46mL 1.73mL |
| 参考文献 |
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