同义名 :	Dihydroorotate Dehydrogenase Inhibitor 11
	CAS号 :	1263303-95-2
	货号 :	A1361930
	分子式 :	C15H11N3O2
	纯度 :	99%+
	分子量 :	265.27
	MDL号 :	MFCD32663119
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in the uridine monophosphate (UMP) biosynthetic pathway and mostly located in the inner membrane of mitochondria, catalyzing the transformation of dihydroorotate to orotate dependent of Mg2+ and ATP[1]. DHODH-IN-11 (Compound 14B), a derivative of Leflunomide, is a weak inhibitor of DHODH with a pKa of 5.03. The weak potency of DHODH-IN-11 may be due to the adverse stereochemistry of the oxime structure[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.77mL 0.75mL 0.38mL	18.85mL 3.77mL 1.88mL	37.70mL 7.54mL 3.77mL

参考文献
[1]Qian Y, et al. Elevated DHODH expression promotes cell proliferation via stabilizing β-catenin in esophageal squamous cell carcinoma. Cell Death Dis. 2020 Oct 15;11(10):862 [2]Giorgis M, et al. 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur J Med Chem. 2011 Jan;46(1):383-92