MAZ51

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Chemical Structure| 163655-37-6 同义名 : -
CAS号 : 163655-37-6
货号 : A1361928
分子式 : C21H18N2O
纯度 : 98%
分子量 : 314.38
MDL号 : MFCD04036983
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 VEGFR-3 is a fms-like tyrosine kinase receptor whose expression is limited almost exclusively to lymphatic endothelium in the adult. VEGFR-3 plays an important role in regulating lymphangiogenesis. MAZ51 is a selective inhibitor of VEGFR-3 tyrosine kinase which inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2[1]. MAZ51 (2.5-10 μM; 24 h) blocked proliferation and induced apoptosis in a wide variety of tumor cells (MT450, 1AS, ASM, G, AT6.1, MTLN3, MTLY, NM-081 cells). In Wistar Furth rats bearing MT450 cells, MAZ51 (8 mg/kg; i.p.; daily for 15 days) significantly suppressed the growth of MT450 tumors[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.18mL

0.64mL

0.32mL

15.90mL

3.18mL

1.59mL

31.81mL

6.36mL

3.18mL
参考文献

[1]Kirkin V, et al. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Eur J Biochem. 2001 Nov;268(21):5530-40

[2]Kirkin V, et al. MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo. Int J Cancer. 2004 Dec 20;112(6):986-93