RBN012759

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Chemical Structure| 2360851-29-0 同义名 : -
CAS号 : 2360851-29-0
货号 : A1359465
分子式 : C19H23FN2O3S
纯度 : 99%+
分子量 : 378.46
MDL号 : MFCD32857169
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 RBN012759 is a potent, selective, and orally active PARP14 inhibitor with an IC50 of less than 3 nM. It exhibits 300-fold selectivity over monoPARPs and 1000-fold over polyPARPs. RBN012759 diminishes pro-tumor macrophage functions and triggers inflammatory responses in tumor explants[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.21mL

2.64mL

1.32mL

26.42mL

5.28mL

2.64mL
参考文献

[1]Schenkel L, et, al. A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants. AACR Annual Meeting 2020.