Nabumetone-d3

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Chemical Structure| 1216770-08-9 同义名 : BRL14777-d3
CAS号 : 1216770-08-9
货号 : A1354460
分子式 : C15H16O2
纯度 : 98% 98%atom%D
分子量 : 231.3
MDL号 : MFCD08063472
存储条件:

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
生物活性
描述 The incorporation of stable heavy isotopes like hydrogen and carbon into pharmaceuticals, primarily as tracers, is increasingly common in drug development for quantifying and analyzing drug metabolism and pharmacokinetics. Deuteration, in particular, is noted for potentially altering the pharmacokinetic and metabolic characteristics of drugs[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.32mL

0.86mL

0.43mL

21.62mL

4.32mL

2.16mL

43.23mL

8.65mL

4.32mL

参考文献

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.