同义名 :	-
	CAS号 :	1595278-21-9
	货号 :	A1351257
	分子式 :	C28H28N4O2
	纯度 :	99%
	分子量 :	452.55
	MDL号 :	MFCD32671947
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

As a NLR family member, NOD2 (nucleotide-binding oligomerization domain 2) is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the production of pro-inflammatory cytokines. GSK717 is a potent and selective NOD2 inhibitor. GSK717 (0.5-16 μM; 1 hour) blocked synergy between NOD2 and TLR2 (Toll-like receptor 2) in primary human monocytes. GSK717 does not affect NOD1, TNFR1 (tumour necrosis factor receptor-1) and TLR2-mediated responses. GSK717 (5 μM) inhibited the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP (muramyl dipeptide). GSK717 inhibited MDP-induced NOD2-mediated signaling with an IC50 of 400 nM for IL-8 secretion stimulated by MDP in HEK293/hNOD2 cells[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.21mL 0.44mL 0.22mL	11.05mL 2.21mL 1.10mL	22.10mL 4.42mL 2.21mL

参考文献

[1]Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1. [2]Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013 Aug 1;8(8):e69619