Tapotoclax
产品说明书
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同义名 : | Amg-176 |
| CAS号 : | 1883727-34-1 | |
| 货号 : | A134428 | |
| 分子式 : | C33H41ClN2O5S | |
| 纯度 : | 97% | |
| 分子量 : | 613.21 | |
| MDL号 : | MFCD31747169 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AMG-176 is an inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and antineoplastic activities. This disrupts the formation of MCL-1/Bcl-2-like protein 11 (BCL2L11; BIM) complexes and induces apoptosis in tumor cells. MCL-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.63mL 0.33mL 0.16mL |
8.15mL 1.63mL 0.82mL |
16.31mL 3.26mL 1.63mL |
| 参考文献 |
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