G140

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Chemical Structure| 2369751-07-3 同义名 : -
CAS号 : 2369751-07-3
货号 : A1340582
分子式 : C17H16Cl2N4O2
纯度 : 99%
分子量 : 379.24
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), demonstrating IC50 values of 14.0 nM for human cGAS (h-cGAS) and 442 nM for mouse cGAS (m-cGAS). It exhibits anti-inflammatory properties[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.64mL

0.53mL

0.26mL

13.18mL

2.64mL

1.32mL

26.37mL

5.27mL

2.64mL
参考文献

[1]Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261.