TH1020
产品说明书
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同义名 : | - |
| CAS号 : | 1841460-82-9 | |
| 货号 : | A1340564 | |
| 分子式 : | C23H15N7S2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 453.54 | |
| MDL号 : | MFCD30480930 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | TH1020 is a potent and selective TLR5/flagellin complex antagonist with an IC50 value of 0.85 μM. TH1020 inhibits flagellin-induced TLR5 signalling, and is inactive against TLR2, TLR3, TLR4, TLR7, and TLR8[1].TH1020 disrupts the binding of flagellin to TLR5 and inhibits downstream signalling mediated by the formation of the TLR5/flagellin complex. At 0.37 μM, TH1020 almost completely inhibited TLR5-mediated TNF-α secretion[1].In bacterial strain C83901-infected IPEC-J2 cells, TH1020 almost completely inhibited IL-17C secretion at a concentration of 0.5 μM[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.20mL 0.44mL 0.22mL |
11.02mL 2.20mL 1.10mL |
22.05mL 4.41mL 2.20mL |
| 参考文献 |
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