AMN082
产品说明书
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同义名 : | - |
| CAS号 : | 97075-46-2 | |
| 货号 : | A1340352 | |
| 分子式 : | C28H30Cl2N2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 465.46 | |
| MDL号 : | MFCD08702723 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AMN082 is a selective, orally active and brain-penetrating mGluR7 agonist that directly activates receptor signalling through allosteric sites in the transmembrane domain. In transfected mGluR7-expressing mammalian cells, AMN082 potently inhibited cAMP accumulation and stimulated GTPγS binding with EC50 values of 64-290 nM. AMN082 is selective for other mGluR subtypes and some ionotropic glutamate receptors. AMN082 exhibits an antidepressant effect[1][2]. Preincubation of synaptosomes with AMN082 (1 μM), 10 min before 4-aminopyridine treatment, effectively inhibited 4-aminopyridine-induced glutamate release without altering basal glutamate release[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.21mL |
10.74mL 2.15mL 1.07mL |
21.48mL 4.30mL 2.15mL |
