THZ-P1-2
产品说明书
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同义名 : | - |
| CAS号 : | 2058075-45-7 | |
| 货号 : | A1339763 | |
| 分子式 : | C31H29N7O2 | |
| 纯度 : | 98% | |
| 分子量 : | 531.61 | |
| MDL号 : | MFCD32858287 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | THZ-P1-2 is a pioneering and selective inhibitor of PI5P4K, with an IC50 of 190 nM for PI5P4Kα. It covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ, leading to autophagy disruption and the upregulation of TFEB signaling. Additionally, THZ-P1-2 exhibits anticancer properties in leukemia cell lines.[1] |
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| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.88mL 0.38mL 0.19mL |
9.41mL 1.88mL 0.94mL |
18.81mL 3.76mL 1.88mL |
