KGA-2727

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Chemical Structure| 666842-36-0 同义名 : -
CAS号 : 666842-36-0
货号 : A1339527
分子式 : C26H40N4O8
纯度 : 99%
分子量 : 536.62
MDL号 : MFCD32701917
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 KGA-2727 stands as the first selective, potent, and orally active inhibitor of SGLT1, with Ki values of 97.4 nM for humans and 43.5 nM for rats. Its selectivity ratios (Ki for SGLT2/Ki for SGLT1) reach 140 for humans and 390 for rats, showcasing antidiabetic effectiveness[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.32mL

1.86mL

0.93mL

18.64mL

3.73mL

1.86mL
参考文献

[1]Shibazaki T, et al. KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2012 Aug;342(2):288-96.