同义名 :	Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate; MC-VC-PAB-PNP
	CAS号 :	159857-81-5
	货号 :	A133919
	分子式 :	C35H43N7O11
	纯度 :	98%+
	分子量 :	737.76
	MDL号 :	MFCD22200431
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Serving as a cathepsin cleavable connector for antibody-drug conjugates (ADCs), Mc-Val-Cit-PABC-PNP links the antibody component to the active drug, facilitating the production of ADCs[1].[2]. The GMP-certified Mc-Val-Cit-PABC-PNP GMP is recognized as a high-quality version of Mc-Val-Cit-PABC-PNP, acting as a cathepsin cleavable linker in ADC manufacture[1]. D-(+)-Malic acid stands as the biologically active form of Malic acid, acting as a competitive blocker against the transport of L(--)malic acid[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.36mL 0.27mL 0.14mL	6.78mL 1.36mL 0.68mL	13.55mL 2.71mL 1.36mL

参考文献
[1]Li Y, et al. Discovery of novel antibody-drug conjugates bearing tissue protease specific linker with both anti-angiogenic and strong cytotoxic effects. Bioorg Chem. 2023 Aug;137:106575. [2]Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.