同义名 :	糠酸莫米松 ;Sch32088
	CAS号 :	83919-23-7
	货号 :	A133834
	分子式 :	C27H30Cl2O6
	纯度 :	99%
	分子量 :	521.43
	MDL号 :	MFCD00866003
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Mometasone furoate is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo. Mometasone furoate exhibits high potency with greater anti-inflammatory activity and a longer duration of action than betamethasone. The molecular biotransformation of mometasone furoate in the skin results in a lower affinity with dermal cells than epidermal cells, which contributes to its low atrophogenicity[3]. Breast cancer patients receiving MF (Mometasone Furoate) during PMRT (postmastectomy radiation) experienced significantly reduced rates of moist desquamation in comparison with a control cream[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.92mL 0.38mL 0.19mL	9.59mL 1.92mL 0.96mL	19.18mL 3.84mL 1.92mL

参考文献

[1]Magari M, Ikeda M, et al. Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice. Immunopharmacol Immunotoxicol. 2006;28(3):491-500. [2]Tsumuro T, Ogawa M, et al. Effects of mometasone furoate on a rat allergic rhinitis model. Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8. [3]Spada F, Barnes TM, Greive KA. Comparative safety and efficacy of topical mometasone furoate with other topical corticosteroids. Australas J Dermatol. 2018 Aug;59(3):e168-e174 [4]Ho AY, Olm-Shipman M, Zhang Z, Siu CT, Wilgucki M, Phung A, Arnold BB, Porinchak M, Lacouture M, McCormick B, Powell SN, Gelblum DY. A Randomized Trial of Mometasone Furoate 0.1% to Reduce High-Grade Acute Radiation Dermatitis in Breast Cancer Patients Receiving Postmastectomy Radiation. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):325-333