Filastatin
产品说明书
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同义名 : | - |
| CAS号 : | 431996-53-1 | |
| 货号 : | A1329233 | |
| 分子式 : | C18H18ClN3O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 359.81 | |
| MDL号 : | MFCD03058358 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Filastatin is a long-lasting inhibitor of Candida albicans filamentation. Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect[1]. Treatment with Filastatin significantly inhibited the ability of C. albicans to adhere to bioactive glass (by 99.06%), silicone (by 77.27%), and dental resin (by 60.43%). Atomic force microcopy indicated that treatment with Filastatin decreased the adhesion force of C. albicans from 0.23 to 0.017 nN. Filastatin treated medical devices prevented adhesion of Candida, thereby reducing nosocomial infections[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.78mL 0.56mL 0.28mL |
13.90mL 2.78mL 1.39mL |
27.79mL 5.56mL 2.78mL |
| 参考文献 |
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