生物活性 | |||
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描述 | AZD-8529 mesylate is a potent, highly selective and orally active mGluR2-positive modulator with an EC50 of 285 nM and no positive modulation of mGluR1, 3, 4, 5, 6, 7 and 8 isoforms at high concentration[1].AZD-8529 mesylate enhances the effect of glutamate on mGluR2 with an EC50 of 195 nM[1].At a concentration of 25 μM, AZD-8529 mesylate does not induce an antagonistic response to mGluR[1]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.71mL 0.34mL 0.17mL |
8.57mL 1.71mL 0.86mL |
17.14mL 3.43mL 1.71mL |