Mezigdomide

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Chemical Structure| 2259648-80-9 同义名 : CC-92480
CAS号 : 2259648-80-9
货号 : A1329223
分子式 : C32H30FN5O4
纯度 : 99%+
分子量 : 567.61
MDL号 : MFCD32263041
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • CRBN
描述 Mezigdomide (CC-92480), classified as a cereblon E3 ubiquitin ligase modulating agent (CELMoD), functions as a molecular adhesive. It exhibits a strong binding affinity to cereblon, thereby demonstrating potent antimyeloma activity [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.81mL

1.76mL

0.88mL

17.62mL

3.52mL

1.76mL
参考文献

[1]Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25(1):19-31.