同义名 :	Atamparib
	CAS号 :	2381037-82-5
	货号 :	A1329221
	分子式 :	C20H23F6N7O3
	纯度 :	99%+
	分子量 :	523.43
	MDL号 :	MFCD32701939
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	PARP7, which is induced by cancer relevant stress (e.g., aryl hydrocarbon receptor ligands such as chemicals found in cigarette smoke and kynurenine), acts as a tumor cell brake in cytosolic nucleic acid sensing and the Type I interferon (IFN) response. RBN-2397 is a potent, selective and orally active NAD+ competitive inhibitor of PARP7 with IC50 <3 nM and KD <1 nM. RBN-2397 blocked proliferation in NCI-H1373 lung cancer cells with a GI50 of 20 nM. Further, RBN-2397 (0.4-1000 nM; 24 hr) restored cytosolic nucleic acid sensing and induced Type I IFNs in NCI-H1373 lung cancer cells in a dose-dependent manner. In vivo, RBN-2397 induced tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses[2].
作用机制	RBN-2397 interacts with adenosine sub-pocket and nicotinamide sub-pocket of PARP7[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.91mL 0.38mL 0.19mL	9.55mL 1.91mL 0.96mL	19.10mL 3.82mL 1.91mL

参考文献
[1]RBN-2397-Inhibiting PARP7, a Key monoPARP Cancer Dependency [2]RBN-2397: A First-in-Class PARP7 Inhibitor Targeting a Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways