同义名 :	-
	CAS号 :	94987-09-4
	货号 :	A1327543
	分子式 :	C42H72O14
	纯度 :	98%
	分子量 :	801.01
	MDL号 :	MFCD31810284
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Gypenoside L is a saponin isolated from Gynostemma pentaphyllum. It caused cell cycle arrest at S phase, reduced the expression of CDK2, CDK4, CDK6, and cyclin D1, activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators, activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence[1]. It also induced cell death, which was associated with lysosomal swelling and autophagic flux inhibition, increased the levels of ROS, triggered protein ubiquitination and ER stress response, leading to Ca2+ release from ER IP3R-operated stores and finally cell death[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.25mL 0.25mL 0.12mL	6.24mL 1.25mL 0.62mL	12.48mL 2.50mL 1.25mL

参考文献

[1]Liao C, Zheng K, Li Y, Xu H, Kang Q, Fan L, Hu X, Jin Z, Zeng Y, Kong X, Zhang J, Wu X, Wu H, Liu L, Xiao X, Wang Y, He Z. Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. Oncotarget. 2016 Jul 26;7(30):47387-47402. doi: 10.18632/oncotarget.10159. PMID: 27329722; PMCID: PMC5216949. [2]Zheng K, Liao C, Li Y, Fan X, Fan L, Xu H, Kang Q, Zeng Y, Wu X, Wu H, Liu L, Xiao X, Zhang J, Wang Y, He Z. Gypenoside L, Isolated from Gynostemma pentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response. J Agric Food Chem. 2016 Mar 2;64(8):1702-11. doi: 10.1021/acs.jafc.5b05668. Epub 2016 Feb 22. PMID: 26870999.