4-Methylumbelliferone

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Chemical Structure| 90-33-5 同义名 : 4-甲基伞形酮 ;Hymecromone; 4-MU; Imecromone; 7-Hydroxy-4-methylcoumarin; 4-Methyl-7-hydroxycoumarin; 4-ΜU
CAS号 : 90-33-5
货号 : A132122
分子式 : C10H8O3
纯度 : 99%
分子量 : 176.17
MDL号 : MFCD00006866
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 4-Methylumbelliferone is an inhibitor of hyaluronic acid biosynthesis, displaying antitumoral and antimetastatic effects.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
293H DA cells Function assay 16 h Agonist activity at PPARgamma LBD in human 293H DA cells after 16 hrs by TR-FRET activation reporter assay, EC50=0.0024 μM 22582973
3T3L1 cell 1 uM Function assay Induction of mouse 3T3L1 cell differentiation assessed as increase in accumulation of intracellular lipid droplet at 1 uM by Oil red O staining 21401118
3T3L1 cells Function assay 7 days Induction of adipogenesis in mouse 3T3L1 cells assessed as increase in lipid accumulation after 7 days by Oil red O staining 20527969
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00304512 Fabry Disease Phase 2 Completed - United States, Georgia ... 展开 >> Decatur, Georgia, United States, 30033 Australia, Victoria Parkville, Victoria, Australia, 3050 Brazil Porto Alegre, Brazil, RS, 90035-903 Canada Montréal, Canada, H4J 1C5 France Paris, France, 75015 United Kingdom Salford, United Kingdom, M6 8HD 收起 <<
NCT00214500 - Completed - -
NCT00526071 Fabry Disease Phase 2 Terminated(The Sponsor (Amicus... 展开 >> Therapeutics) terminated this study for logistical reasons.) 收起 << - United States, Georgia ... 展开 >> Decatur, Georgia, United States, 30033 United States, New York New York, New York, United States, 10016 United States, Texas Dallas, Texas, United States, 78226 Australia Parkville, Australia Brazil Porto Alegre, Brazil France Garches, France United Kingdom London, United Kingdom Salford, United Kingdom 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.68mL

1.14mL

0.57mL

28.38mL

5.68mL

2.84mL

56.76mL

11.35mL

5.68mL
参考文献

[1]Nagy N, Kuipers HF, et al. 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 2015 Mar 23;6:123.

[2]Kuroda Y, Kasai K, et al. 4-Methylumbelliferone inhibits the phosphorylation of hyaluronan synthase 2 induced by 12-O-tetradecanoyl-phorbol-13-acetate. Biomed Res. 2013 Apr;34(2):97-103.