Doxorubicin HCl
产品说明书
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同义名 : | 盐酸阿霉素 ;Hydroxydaunorubicin hydrochloride; Doxorubicin (hydrochloride); DOX; Hydroxydaunorubicin HCl; NSC 123127; Adriamycin; Doxorubicin HCl |
| CAS号 : | 25316-40-9 | |
| 货号 : | A130952 | |
| 分子式 : | C27H30ClNO11 | |
| 纯度 : | 99+% | |
| 分子量 : | 579.98 | |
| MDL号 : | MFCD00077757 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
PO 0.5% CMC-Na 50 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Doxorubicin hydrochloride, a potent chemotherapeutic agent and cytotoxic anthracycline antibiotic, inhibits human DNA topoisomerase I and II with IC50 values of 0.8 µM and 2.67 µM, respectively. It diminishes the basal phosphorylation of AMPK and acetyl-CoA carboxylase, leading to the induction of apoptosis and autophagy[1][2][3]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| 16HBE | 10 μM | Growth Inhibition Assay | 72 h | GI50=0.18 μM | 24650643 |
| 1A9 | Cytotoxic Assay | ED50=0.02 μM | 17591444 | ||
| 2008/MRP1 | Cytotoxic Assay | 5 d | IC50=0.577 μM | 19725578 | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.72mL 0.34mL 0.17mL |
8.62mL 1.72mL 0.86mL |
17.24mL 3.45mL 1.72mL |
| 参考文献 |
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