Neostigmine methyl sulfate

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Chemical Structure| 51-60-5 同义名 : 甲基硫酸新斯的明 ;Neostigmine (methyl sulfate); Hodostin; NSC 93753; Neostigmeth; Syntostigmin
CAS号 : 51-60-5
货号 : A129666
分子式 : C13H22N2O6S
纯度 : 98%
分子量 : 334.39
MDL号 : MFCD01558739
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Neostigmine Methyl Sulfate is acetylcholine esterase inhibitors as neuraxial adjuvant drug. The ED50 and ED95 of epidural neostigmine in combination with PCEA (patient controlled epidural analgesia ) for satisfactory analgesia after partial hepatectomy were 228.63 μg (95% CI = 197.95–299.77 μg) and 300.12 μg (95% CI = 259.44–741.65 μg)[2]. Moreover, the immediate and dramatic reversal of envenomation symptoms following the administration of the anticholinesterase neostigmine methyl sulfate[3]. The N-monophenylcarbamate analogues of neostigmine methyl sulfate have extended duration of cholinesterase inhibition as long-acting agents for myasthenia gravis[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.95mL

2.99mL

1.50mL

29.91mL

5.98mL

2.99mL
参考文献

[1]Huang TH, Pan DH, et al. [Applications of A C oscillopolarographic titration in pharmaceutical analysis. I. Titration of neostigmine methyl sulfate injection with sodium tetraphenylborate] . Yao Xue Xue Bao. 1982 Jul;17(7):534-9.

[2]Zhong QS, Ge SJ, Wang B, Xue ZG. Optimal single-dose epidural neostigmine for postoperative analgesia after partial hepatectomy. Indian J Pharmacol. 2014 Nov-Dec;46(6):613-6.

[3]Gold BS. Neostigmine for the treatment of neurotoxicity following envenomation by the Asiatic cobra. Ann Emerg Med. 1996 Jul;28(1):87-9.

[4]Yu QS, Holloway HW, Luo W, Lahiri DK, Brossi A, Greig NH. Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.