Temsavir
产品说明书
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同义名 : | - |
| CAS号 : | 701213-36-7 | |
| 货号 : | A128252 | |
| 分子式 : | C24H23N7O4 | |
| 纯度 : | 98% | |
| 分子量 : | 473.48 | |
| MDL号 : | MFCD22665723 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Temsavir demonstrates exceptional efficacy against a wide range of viral isolates, with EC50 values below 10 nM for the majority. It specifically shows an average EC50 of 0.7±0.4 nM against LAI virus, varying from 0.01 nM against the most susceptible virus to more than 2,000 nM against the least susceptible. Temsavir's cytotoxicity has been assessed across multiple cell types from different human tissues, revealing CC50 values greater than 200 μM in various cell lines, including MT-2, HEK293, HEp-2, HepG2, HeLa, HCT116, MCF-7, SK-N-MC, HOS, H292, and MDBK, after either 3 or 6 days of culture. However, lower CC50 values of 105 and 192 μM were noted in PM1 T cells and PBMCs, respectively, after 6 days, indicating low cytotoxicity in cell culture[1]. Moreover, Temsavir shows a broad antiviral activity spectrum against a panel of clinical isolates, with IC50 values ranging from subnanomolar levels to more than 0.1 µM, highlighting its broad-spectrum antiviral efficacy[2]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.11mL 0.42mL 0.21mL |
10.56mL 2.11mL 1.06mL |
21.12mL 4.22mL 2.11mL |
| 参考文献 |
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