Icenticaftor
产品说明书
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同义名 : | QBW251; NVP-QBW251 |
| CAS号 : | 1334546-77-8 | |
| 货号 : | A1277845 | |
| 分子式 : | C12H13F6N3O3 | |
| 纯度 : | 98% | |
| 分子量 : | 361.24 | |
| MDL号 : | MFCD31631074 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Icenticaftor, also known as QBW251, is an orally active CFTR channel potentiator with EC50 values of 79 nM and 497 nM for F508del CFTR and G551D CFTR, respectively.Icenticaftor is used in chronic obstructive pulmonary disease (COPD) and cystic fibrosis studies[1].Icenticaftor is an orally bioactive small molecule CFTR potentiator that restores the function of specific mutant and wild-type CFTRs[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.77mL 0.55mL 0.28mL |
13.84mL 2.77mL 1.38mL |
27.68mL 5.54mL 2.77mL |
