Tiopronin

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Chemical Structure| 1953-02-2 同义名 : 2-(2-巯基丙酰胺基)乙酸 ;BRN 1859822; (±)-Tiopronin; Vincol; Epatiol; Capen; Acadione
CAS号 : 1953-02-2
货号 : A127313
分子式 : C5H9NO3S
纯度 : 98%
分子量 : 163.19
MDL号 : MFCD00004861
存储条件:

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Tiopronin, known for its multifaceted therapeutic roles, functions as a diffusible antioxidant, an antidote to heavy metal poisoning, and a radioprotective agent. It effectively manages the rate of cystine precipitation and excretion, showing promise in the treatment of cystinuria, rheumatoid arthritis, and hepatic disorders[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.13mL

1.23mL

0.61mL

30.64mL

6.13mL

3.06mL

61.28mL

12.26mL

6.13mL

参考文献

[1]Pu Zhang, et al. Detection of tiopronin in body fluids and pharmaceutical products using red-emissive DNA-stabilized silver nanoclusters as a fluorescent probe. Mikrochim Acta. 2019 Aug 8;186(9):609.

[2]Soohwan Yum, et al. N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1008-13.