Piperine
产品说明书
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同义名 : | Bioperine; 1-Piperoylpiperidine; N-Piperoylpiperidin; NSC 21727 |
| CAS号 : | 94-62-2 | |
| 货号 : | A126615 | |
| 分子式 : | C9H15NO5 | |
| 纯度 : | 97% | |
| 分子量 : | 285.34 | |
| MDL号 : | MFCD00005839 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Piperine is a natural alkaloid isolated from pepper and inhibits the activity of P-glycoprotein and CYP3A4 with IC50[3]. In vivo, at the dose of 3.5 mg/kg, the bioavailability of Piperine was calculated to be 25.36% and its AUC0→t was unproportionally increased with doses[4]. Moreover, piperine effectively reduced the aureus-induced overexpression of TNF-α, IL-1β, and IL-6 but increased the expression of IL-10. The phosphorylation of I-κB, p65, p38, ERK, and JNK was inhibited by piperine in a dose-dependent manner[5]. Piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01640197 | Healthy | Phase 1 | Completed | - | United Kingdom ... 展开 >> Brain performance and nutrition research centre, Northumbria university Newcastle upon Tyne, Tyne and Wear, United Kingdom, NE1 8ST 收起 << |
| NCT00065741 | HIV Seronegativity | Phase 1 | Completed | - | United States, North Carolina ... 展开 >> General Clinical Research Center, Univiversity Of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599 收起 << |
| NCT01640197 | - | Completed | - | - | |
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.50mL 0.70mL 0.35mL |
17.52mL 3.50mL 1.75mL |
35.05mL 7.01mL 3.50mL |
| 参考文献 |
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