Econazole nitrate
产品说明书
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同义名 : | SQ 13,020; NSC 243115; Econazole (nitrate) |
| CAS号 : | 24169-02-6 | |
| 货号 : | A126576 | |
| 分子式 : | C18H16Cl3N3O4 | |
| 纯度 : | 98% | |
| 分子量 : | 444.7 | |
| MDL号 : | MFCD00058160 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
IP 2% DMSO+2% Tween80+40% PEG300+water 8 mg/mL clear PO 0.5% CMC-Na 31 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Econazole Nitrate is an imidazole class antifungal medication. Vaginal candidiasis in rats was cured after oral administration of econazole. Toxicity and teratogenicity studies in different laboratory animals indicate that econazole is well tolerated[3]. Econazole nitrate loaded transethosomes are effective to deliver econazole nitrate transdermally in a controlled fashion for effective elimination of cutaneous candidiasis[4]. In acidic solutions ECN/αCD (Econazole Nitrate/α-cyclodextrin) can enhance the antifungal activity to filamentous fungi[5]. Reductions in VAS (visual analog scale) scores of econazole nitrate topical foam were significantly greater than those of ketoconazole cream, indicating the superiority of the econazole nitrate foam in reducing pruritus[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.25mL 0.45mL 0.22mL |
11.24mL 2.25mL 1.12mL |
22.49mL 4.50mL 2.25mL |
| 参考文献 |
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