CAIX Inhibitor S4

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Chemical Structure| 1330061-67-0 同义名 : -
CAS号 : 1330061-67-0
货号 : A1258800
分子式 : C15H17N3O4S
纯度 : 99%+
分子量 : 335.38
MDL号 : MFCD30182321
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CAIX Inhibitor S4 is a potent, selective inhibitor of CA IX/XII with Ki values of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki of 546 nM and 5600 nM, respectively). CAIX Inhibitor S4 inhibits orthotopic MDA-MB-231 mouse model of the number of lung metastases without affecting primary tumour growth. In the concentration range of 1-100 μM for 24 h, CAIX Inhibitor S4 inhibited the proliferation of MDA-MB-231, HCT116 and HT29 cells in a dose-dependent manner. While in the concentration range of 3.3-33 μM, CAIX Inhibitor S4 inhibited the migration of eGFP-MDA-MB-231 cells under hypoxia in a concentration-dependent manner. At a concentration of 33 μM for 15-60 minutes, CAIX Inhibitor S4 retarded the spreading of MDA-MB-231 cells in hypoxia, but essentially not in normoxia[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.98mL

0.60mL

0.30mL

14.91mL

2.98mL

1.49mL

29.82mL

5.96mL

2.98mL