Hck-IN-1
产品说明书
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同义名 : | - |
| CAS号 : | 1473404-51-1 | |
| 货号 : | A1258085 | |
| 分子式 : | C16H11ClN6O3S | |
| 纯度 : | 99%+ | |
| 分子量 : | 402.81 | |
| MDL号 : | MFCD32671892 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Hck is a member of the Src-family that serves a key effector role in Nef-dependent human immunodeficiency virus (HIV)-1 replication. Hck-IN-1 is a selective Nef-dependent Hck inhibitor with IC50 values of 2.8μM and >20μM for the Nef:Hck complex and Hck alone, respectively, in vitro. In CEM-T4 cells, Hck-IN-1 inhibited wild-type HIV-1 replication with IC50 values of 100 – 300nM, while replication of Nef-defective HIV-1 was not affected at 3.0μM. Hck-IN-1 also inhibited the replication of all eleven HIV-1 Nef chimeras tested in CEM-T4 cell with an IC50 value of ~300nM. In HIV-infected cells, B9 completely inhibited Nef-dependent SFK activation at a concentration of 1.0μM. B9 inhibited the replication of simian immunodeficiency virus with an IC50 value of ~1.0 μM[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.48mL 0.50mL 0.25mL |
12.41mL 2.48mL 1.24mL |
24.83mL 4.97mL 2.48mL |
| 参考文献 |
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