同义名 :	-
	CAS号 :	1417700-13-0
	货号 :	A1257467
	分子式 :	C26H31N3O3
	纯度 :	99%+
	分子量 :	433.54
	MDL号 :	MFCD32693920
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

The coronavirus 3 chymotrypsin-like protease (3CL(pro)) is a validated target in the design of potential anticoronavirus inhibitors. The compound ML188, also termed 16R, works as an inhibitor of the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) 3CL(pro)[1]. ML188 represents the first true non-covalent 3CLpro inhibitor with modest molecular weight (MW) and good inhibitory activity below 2 μM[2]. ML188 inhibits SARS-CoV-2 Mpro at 2.5µM, which is more potent than against SAR-CoV-1 Mpro[3]. ML188 yields an antiviral EC50 values ranging from 12.9 to 13.4μM in mock-infected and SARS-CoV infected cells.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.31mL 0.46mL 0.23mL	11.53mL 2.31mL 1.15mL	23.07mL 4.61mL 2.31mL

参考文献

[1]Michael Berry,et al. Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: homology modelling and molecular dynamic studies. BMC Struct Biol. 2015 Apr 28;15:8. doi: 10.1186/s12900-015-0035-3. [2]Jon Jacobs,et al. Discovery of non-covalent inhibitors of the SARS main proteinase 3Clpro. National Center for Biotechnology Information (US); 2010–.2010 Oct 30 [3]Gordon J Lockbaum,et al. Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188. Viruses. 2021 Jan 25;13(2):174.