DRI-C21045
产品说明书
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同义名 : | - |
| CAS号 : | 2101765-81-3 | |
| 货号 : | A1251847 | |
| 分子式 : | C32H24N2O7S | |
| 纯度 : | 98% | |
| 分子量 : | 580.61 | |
| MDL号 : | MFCD32201050 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | DRI-C21045 is a potent and selective inhibitor of CD40-CD40L costimulatory protein-protein interactions (PPIs) with an IC50 of 0.17 µM. DRI-C21045 showed a concentration-dependent inhibition of both CD40L-induced NF-κB activation and B-cell proliferation, with IC50s of 17.1 µM and 4.5 µM, respectively[1].In the concentration range of 0.6-50 μM for 48 hours, DRI-C21045 blocked CD40L-induced functional activation of primary B cells and inhibited CD40L-induced up-regulation of MHC-II in THP-1 cells. And in the concentration range of 2-100 μM, DRI-C21045 inhibited CD40L-induced B cell proliferation[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.72mL 0.34mL 0.17mL |
8.61mL 1.72mL 0.86mL |
17.22mL 3.44mL 1.72mL |
