LP-935509
产品说明书
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同义名 : | - |
| CAS号 : | 1454555-29-3 | |
| 货号 : | A1251842 | |
| 分子式 : | C20H24N6O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 396.44 | |
| MDL号 : | MFCD31689756 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | LP-935509 is an orally active, potent, selective, ATP-competitive, and brain-penetrating inhibitor of AAK1 with an IC50 value of 3.3 nM and a Ki value of 0.9 nM. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a mild inhibitor of GAK (IC50=320 nM). LP-935509 has antinociceptive activity and can be used in neuropathic pain and SARS-CoV-2 studies.The IC50 value of LP-935509 for inhibition of μ2 protein phosphorylation is 2.8 ± 0.4 nM, and for inhibition of μ2 protein polypeptide phosphorylation is 3.3 ± 0.7 nM[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.52mL 0.50mL 0.25mL |
12.61mL 2.52mL 1.26mL |
25.22mL 5.04mL 2.52mL |
