同义名 :	莫特塞尼 ;AMG 706
	CAS号 :	453562-69-1
	货号 :	A123381
	分子式 :	C22H23N5O
	纯度 :	99%+
	分子量 :	373.45
	MDL号 :	MFCD10567689
	存储条件：	Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Motesanib is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively, showing similar activity against Kit and being ~10-fold selective for VEGFR than PDGFR and Ret.

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00861419	Advanced Solid Tumors	Phase 1	Completed	-	-
NCT02084732	Thyroid Cancer	Phase 2	Unknown	June 2018	Colombia ... 展开 >> Instituto Nacional de Cancerología Recruiting Bogotá, Cundinamarca, Colombia, 00000 Contact: Yeinnyer C. Muleth, BSc    3340106    ymuleth@cancer.gov.co    Principal Investigator: Luis F Fierro, Md          Sub-Investigator: Gloria Garavito, Md          Sub-Investigator: Andres A Cuellar, Md          Sub-Investigator: Jose A. Carreño, Md          Sub-Investigator: Juan S Castillo, Md 收起 <<
NCT01700699	-		Unknown	October 2013	Italy ... 展开 >> Department of Medicine and Surgery, Univeristy of Salerno Recruiting Baronissi, Salerno, Italy, 84081 Contact: Mario Vitale, MD    +39 089672539    mavitale@unisa.it    Principal Investigator: Mario Vitale, MD 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.68mL 0.54mL 0.27mL	13.39mL 2.68mL 1.34mL	26.78mL 5.36mL 2.68mL

参考文献

[1]Kruser TJ, Wheeler DL, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res. 2010 Jul 15;16(14):3639-47. [2]Polverino A, Coxon A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21.