SIRT2-IN-11

产品说明书

Print
Chemical Structure| 1005095-06-6 同义名 : -
CAS号 : 1005095-06-6
货号 : A1229338
分子式 : C21H22N2O
纯度 : 99%+
分子量 : 318.41
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor, displaying an IC50 value of 18.5 μM. SIRT2-IN-11 induces apoptosis in a p53-dependent manner, upregulates the expression of CDKN1A, PUMA, and NOXA, and enhances p53 acetylation. It is applicable for investigating p53-related cancers [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.70mL

3.14mL

1.57mL

31.41mL

6.28mL

3.14mL
参考文献

[1]Cameron KO, et al. Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett. 2009 Apr 1;19(7):2075-8.