(S)-Volinanserin

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Chemical Structure| 175673-57-1 同义名 : (S)-MDL100907; (S)-M 100907
CAS号 : 175673-57-1
货号 : A1228907
分子式 : C22H28FNO3
纯度 : 98%+
分子量 : 373.46
MDL号 : MFCD10565916
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Volinanserin (MDL 100907) functions as a potent antagonist at the 5-HT2 receptor, displaying a Ki value of 0.36 nM and exhibiting a 300-fold selectivity for the 5-HT2 receptor over the 5-HT1c receptor, alpha-1, and DA D2 receptors. Its activity includes antipsychotic effects[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.39mL

2.68mL

1.34mL

26.78mL

5.36mL

2.68mL
参考文献

[1]Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91.

[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.