同义名 :	TZV; Riamilovir
	CAS号 :	928659-17-0
	货号 :	A1228484
	分子式 :	C5H7N6NaO5S
	纯度 :	99%+
	分子量 :	286.2
	MDL号 :	MFCD30532663
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Triazavirin is a novel antiviral drug that has proven activity against influenza and other viruses, including tick-borne encephalitis.Kozhikhova KV, Ivantsova MN, Tokareva MI, Shulepov ID, Tretiyakov AV, Shaidarov LV, Rusinov VL, Mironov MA. Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drug Triazavirin. Pharm Dev Technol. 2018 Apr;23(4):334-342. doi: 10.1080/10837450.2016.1242624 In the SKEV cell culture, Triazavirin at a concentration of 128mcg/mL inhibited tick-borne encephalitis virus reproduction.[1] Triazavirin at high doses (200–400mg/kg) moderately protected albino mice infected with Forest-Spring encephalitis. Triazavirin-treated animals showed significantly increased lifespan (4.1–4.8 days) and significantly reduced virus accumulation in the brain compared to the control group.[2]
作用机制	Triazavirin is a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA, as well as the replication of genomic fragments.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.49mL 0.70mL 0.35mL	17.47mL 3.49mL 1.75mL	34.94mL 6.99mL 3.49mL

参考文献

[1]Loginova SIa, Borisevich SV, Rusinov VL, Ulomskiĭ UN, Charushin VN, Chupakhin ON. [Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture]. Antibiot Khimioter. 2014;59(1-2):3-5 [2]Loginova SY, Borisevich SV, Rusinov VL, Ulomsky EN, Charushin VN, Chupakhin ON, Sorokin PV. [Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice]. Antibiot Khimioter. 2015;60(7-8):11-3