Amygdalin

产品说明书

Print
Chemical Structure| 29883-15-6 同义名 : 苦杏仁苷 ;Amygdaloside; NSC 15780; (R)-Amygdalin; (D)-Amygdalin; (–)-Amygdalin
CAS号 : 29883-15-6
货号 : A122268
分子式 : C20H27NO11
纯度 : 95%
分子量 : 457.43
MDL号 : MFCD00006598
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Amygdalin, a natural compound found in the bitter apricot kernel, has many biological activities[1]. In vitro studies, amygdalin could delay the progression of cell cycle in LNCaP, DU-145 and PC3 cells, as well as inhibit the cell growth of LNCaP and PC3 cells[2]. Besides this, it was found that amygdalin could block the metastatic spread in RCC cell lines, through the downregulation of α5 and α6 integrins[3]. In vivo studies, amygdalin has the ability of attenuating the acute lung injury induced by lipopolysaccharide in mice, possibly by the inhibition of NF-κB and NLRP3 signaling pathways[1]. In addition, amygdalin could contribute to the improvement of atherosclerosis and the stability of plaque in mice[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.93mL

2.19mL

1.09mL

21.86mL

4.37mL

2.19mL
参考文献

[1]Zhang A, Pan W, Lv J, Wu H. Protective Effect of Amygdalin on LPS-Induced Acute Lung Injury by Inhibiting NF-κB and NLRP3 Signaling Pathways. Inflammation. 2017;40(3):745-751.

[2]Makarevic J, Tsaur I, et al. Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro. Life Sci. 2016.

[3]Juengel E, Afschar M, et al. Amygdalin blocks the in vitro adhesion and invasion of renal cell carcinoma cells by an integrin-dependent mechanism. Int J Mol Med. 2016;37(3):843-50.

[4]Lv J, Xiong W, et al. Amygdalin ameliorates the progression of atherosclerosis in LDL receptor‑deficient mice. Mol Med Rep. 2017;16(6):8171-8179.