PF-06446846 HCl

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Chemical Structure| 1632250-50-0 同义名 : PF-06446846 hydrochloride; PF846
CAS号 : 1632250-50-0
货号 : A1216950
分子式 : C22H21Cl2N7O
纯度 : 98%
分子量 : 470.35
MDL号 : MFCD31693841
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 PF-06446846 hydrochloride is an orally active PCSK9 inhibitor. PF-06446846 hydrochloride directly and selectively inhibits PCSK9 translation by blocking 80S ribosomes near the codon region. PF-06446846 hydrochloride inhibits the secretion of PCSK9 from PF-06446846 hydrochloride inhibits PCSK9 secretion by Huh7 cells with an IC50 value of 0.3 μM[1] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.63mL

2.13mL

1.06mL

21.26mL

4.25mL

2.13mL