PTP1B-IN-22

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Chemical Structure| 86109-60-6 同义名 : -
CAS号 : 86109-60-6
货号 : A1216918
分子式 : C16H12N2O3S2
纯度 : 99%+
分子量 : 344.41
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PTP1B-IN-22, derived from ZINC02765569, is identified as an efficacious inhibitor of protein tyrosine phosphatase 1B (PTP1B). It exhibits notable inhibitory action against PTP1B alongside enhancing glucose uptake within skeletal muscle L6 myotubes, showing a 66.4% inhibition in vitro and a 39.6% uptick in glucose absorption[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.52mL

2.90mL

1.45mL

29.04mL

5.81mL

2.90mL
参考文献

[1]Prashant J, et, al. Molecular modeling and synthesis of ZINC02765569 derivatives as protein tyrosine phosphatase 1B inhibitors: lead optimization study. 2012;22: 1618-23.