C-021
产品说明书
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同义名 : | - |
| CAS号 : | 864289-85-0 | |
| 货号 : | A1216866 | |
| 分子式 : | C27H41N5O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 467.65 | |
| MDL号 : | MFCD18661383 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | C-021 is a potent CCR4 antagonist. C-021 effectively inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].The in vitro oxidative metabolic stability value, i.e., the intrinsic clearance value (CLint) of C-021 was derived to be 17,377 mL/h/kg as assessed by measuring the rate of consumption of the drug in human liver microsomes (HML) [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.14mL 0.43mL 0.21mL |
10.69mL 2.14mL 1.07mL |
21.38mL 4.28mL 2.14mL |
